HOUSE OF REPRESENTATIVES             H.R. NO.30            
TWENTIETH LEGISLATURE, 1999                                
STATE OF HAWAII                                            
                                                                
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                        HOUSE  RESOLUTION

HONORING AND COMMENDING DR. RYUZO YANAGIMACHI, DR. JOHN I.
     STILES, DR. GREGORY M.L. PATTERSON, AND DR. RICHARD E. MOORE
     FOR THEIR NOTABLE ACHIEVEMENTS IN SCIENCE AND RESEARCH AT
     THE UNIVERSITY OF HAWAII AND FOR THEIR OUTSTANDING
     CONTRIBUTIONS TO THE STATE.
  
  
  
   1        WHEREAS, visionary minds, steadfast commitment, and unique
   2    talents, combined with hours of long and arduous work, led four
   3    researchers from the University of Hawaii to the road of
   4    scientific discovery and achievement; and
   5    
   6        WHEREAS, the State is proud to be home to DR. RYUZO
   7    YANAGIMACHI, DR. JOHN I. STILES, DR. GREGORY M.L. PATTERSON,
   8    AND DR. RICHARD E. MOORE for their brilliant scientific
   9    contributions; and
  10    
  11        WHEREAS, in recognition of their achievements in research,
  12    the Legislature is honored to recognize the following
  13    individuals:
  14    
  15        (1)  DR. RYUZO YANAGIMACHI, Professor of Anatomy and
  16             Reproductive Biology at the University of Hawaii at
  17             Manoa's John A. Burns School of Medicine, Department
  18             of  Anatomy and Reproductive Biology.  In the past 30
  19             years, DR. YANAGIMACHI's studies and those of the
  20             research teams under his direction have resulted in
  21             numerous discoveries of major importance to the
  22             understanding of fertilization and embryonic
  23             development.  He is recognized for formulating a
  24             method for achieving in vitro activation of sperm so
  25             that fertilization can occur.  This method was
  26             reported in the journal, Nature, in 1963, and is
  27             recognized as the fundamental contribution that led to
  28             the first successful in vitro fertilization of a human
  29             egg, as well as in vitro fertilization of cattle,
  30             sheep, and goat eggs.  He has been distinguished as
  31             the "Islander of the Year" who has brought worldwide
  32             recognition to Hawaii for his research, particularly
  33             his discovery of mammal cloning;

 
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   1        (2)  DR. JOHN I. STILES, Associate Plant Molecular
   2             Physiologist at the University of Hawaii at Manoa's
   3             Department of Plant Molecular Physiology, College of
   4             Tropical Agriculture and Human Resources, has been on
   5             leave from the University of Hawaii since 1997, and
   6             currently serves as Director of Research of American
   7             Tropical Plants and Director of Integrated Coffee
   8             Technologies.  DR. STILES is recognized for several
   9             biotechnology products resulting from his research:
  10    
  11             (a)  Controlled-ripening papaya, a genetically-
  12                  engineered papaya that will ripen more slowly or
  13                  even allow control of ripening, thus extending
  14                  the shelf life of papaya and resulting in a
  15                  better quality fruit; and
  16    
  17             (b)  Controlled-ripening coffee, a genetically-
  18                  engineered coffee plant that will allow uniform
  19                  ripening, thus greatly increasing the efficiency
  20                  of mechanical harvesting; and
  21    
  22             (c)  Caffeine-free coffee, engineered to be caffeine-
  23                  free and are now entering field trials.  Research
  24                  on this product is being done in collaboration
  25                  with Dr. Stefan Moisyadi and Dr. Kabi Neupane;
  26    
  27        (3)  DR. GREGORY M.L. PATTERSON, Researcher at the
  28             University of Hawaii at Manoa's Department of
  29             Chemistry, and Director of the Natural Products
  30             Program at the Cancer Research Center of Hawaii.  DR.
  31             PATTERSON is known for his research on algae,
  32             particularly on the discovery of new potentially-
  33             useful products from cyanobacteria (blue-green algae).
  34             DR. PATTERSON has found that one class of metabolites
  35             called cryptophycins is showing enough promise for
  36             controlling human cancer to warrant clinical trials,
  37             which are now in progress.  His work has yielded ten
  38             U.S. patents and numerous foreign patents for useful
  39             products from cyanobacteria and the processes for
  40             making the products;
  41    
  42        and
  43    
  44        (4)  DR. RICHARD E. MOORE, Professor of Chemistry at the
  45             University of Hawaii at Manoa's Department of
  46             Chemistry.  DR. MOORE is recognized for identification
  47             of the potent inflammatory agents and tumor-promoting

 
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   1             factors in Lyngbya majuscule, the seaweed that is
   2             responsible for outbreaks of seaweed dermatitis on the
   3             windward side of Oahu.  DR. MOORE has also conducted
   4             pioneering studies on new natural products from
   5             laboratory-cultured blue-green algae.  He has over 100
   6             patents issued or pending that relate to his research
   7             specializations of structure, synthesis, and
   8             biosynthesis of natural products from microalgae and
   9             marine organisms;
  10    
  11    and
  12    
  13        WHEREAS, each of these distinguished individuals and their
  14    outstanding accomplishments have brought worldwide recognition
  15    to our Fiftieth State for their science and research advances;
  16    now, therefore,
  17    
  18        BE IT RESOLVED by the House of Representatives of the
  19    Twentieth Legislature of the State of Hawaii, Regular Session
  20    of 1999, that this body honors and commends DR. RYUZO
  21    YANAGIMACHI, DR. JOHN I. STILES, DR. GREGORY M.L. PATTERSON,
  22    AND DR. RICHARD E. MOORE for their notable achievements in
  23    science and research at the University of Hawaii and for their
  24    outstanding contributions to the State.
  25  
  26  
  27                          OFFERED BY:  ____________________________